Etizolam is a thienodiazepine anxiolytic. Etizolam is chemically related to the commonly prescribed substances known as Benzodiazepines. Benzodiazepines are used for treating depression, anxiety, and insomnia.
Etizolam is used as a treatment for anxiety, depression, and a short-term treatment for insomnia. Etizolam gives a person a sense of well-being, euphoria, muscle relaxation, a feeling of calm, and can cause sedation or sleepiness.
Routes of Administration
Etizolam is typically consumed by the oral administration but can be taken sublingual/transbuccal, by insufflation, or can be inserted rectally.
Oral doses can take from 30-60 to start working and begin to peak after three-four hours. The duration normally lasts between one-five hours but can last longer with higher doses.
- 0.5 mg Light
- 1-2 mg Common
- 3-4 mg Strong
- 5 mg + Heavy
Sublingual (under the tongue) and Transbuccal (inside the cheek) administrations typically have a quicker onset and can last between one-five hours.
Insufflation is a viable way of administration if you have a pure powdered form of Etizolam. There is a faster onset by insufflation than by oral, but the duration is the same.
Etizolam can be administered rectally when dissolved in a solvent. The duration is the same, but the onset approaches much faster.
Etizolam can cause increased tolerance, dependence, and addiction when taken for a long period of time. They slow down the brain and may cause short-term memory loss.
They also help people sleep, cause a calming sensation, and help to stop fits.
Etizolam has a variety of risks. Etizolam can be very addictive which can cause people to abuse it. Overuse of Etizolam can cause slowed breathing, excessive sleepiness, and overdose. There have been cases where it’s linked to seizures, heart failure, and respiratory failure.
- Memory Loss
- Loss of Coordination
- Motor Skill Impairment
- Lack of Energy
- Personality Changes
- Emotional/Social Dissociation
When taking Etizolam for an extended period of time, it can cause anxiety, depression, and sleeplessness, which is what it’s intended to treat.
Tolerance, Dependence, and Withdrawal
Like Benzodiazepines, Etizolam can cause tolerance and dependence. When taking Etizolam for an extended amount of time, an individual can build tolerance against the drug. Once a person is aware of their tolerance, they may be tempted a higher dosage of Etizolam than needed. Taking a higher dosage of Etizolam, without medical supervision, could cause harm in the future. A person could become dependent on this drug if not taken properly. The higher dosage of Etizolam administered, the harder it will be to withdrawal from the drug. Withdrawal symptoms include:
- Cold Sweats
- Reduced circulation
- Drop in Blood Pressure
An Overdose of Etizolam can cause unconsciousness, coma, and death. A person should not exceed the proper dosage of this drug. One should never let an individual sleep off the effects of an overdose, he/she must seek medical attention immediately. Symptoms of overdose include:
- Blurred Vision
- Trouble Breathing
- Muscle Weakness
- Low Blood Pressure
- Irregular Heart Beat
Etizolam acts on the GABAA receptor which has anxiolytic, sedative, muscle relaxant, anticonvulsant, and hypnotic factors.
When tested on laboratory animals, the results showed muscle relaxation, anxiety relief, behavioral changes, and anti-convulsion activity during numerous studies.
Molecular Formula: C17H15CIN4S
Molecular Weight: 342.87
Density: 1.43 g/cm3
Melting Point: 147-148 °C
Boiling point: 545.3 °C at 760 mmHg
Flash point: 283.6 °C
Etizolam is a weak base. It has a pKa value of 2.76.9
Reagent Test Results
When given a Reagent test, Etizolam produced these results in order:
- Clear yellow tinge
- No reaction
- Neon yellow
- Greenish faint
Etizolam is produced by licensed pharmaceutical companies and is sold over the internet or by retail shops.
Etizolam is not FDA approved in the U.S. but is allowed for research purposes. Etizolam is a controlled substance in Alabama, Arkansas, Florida, Mississippi, Virginia, and Georgia. Etizolam is not controlled in the United Kingdom but is controlled in Denmark and Germany. Etizolam is restricted as a benzodiazepine analog in Japan.
Etizolam has been known to be sold as a powder, in tablet/pellet form, and fixed onto the surface of blotter paper.
In 1984, Etizolam was originated and developed in Japan under the name Depas. Etizolam’s popularity increased in 2011 and has continued to raise since. Though unscheduled worldwide, the drug is available for purchase online from other countries for chemical research.